The Effect of Artemisinin on Oxidative Stress Markers in Mouse Heart and Lung Tissues in an Experimental Model of Epileptic Seizure.

Aim: The current study investigated the effects of artemisinin on heart and lung tissue against pentylenetetrazol-induced seizures in mice. For this purpose, malondialdehyde (MDA), advanced oxidation protein products (AOPP), Catalase (CAT), glutathione (GSH), peroxidase (GSH-Px) levels were evaluated both homogenates.Material Method: Swiss albino male mice (n=42) used experiment. Animals divided into six groups; Control (C), pentylenetetrazol (PTZ), valproate 100 mg/kg (VPA), 30 (ARS)+PTZ, ARS 60 mg/kg+PTZ, 120 mg/kg+PTZ. On 26th day experiment, sacrificed samples kept at -80 0C for biochemical analysis.Results: There significant differences five parameters analyzed tissues. Heart MDA PTZ group found to be significantly higher than C ARS-60 groups (p<0.05). groups. Likewise, AOPP decreased VPA compared was no difference between terms (p>0.05). CAT GSH other However, Lung levels, had highest value groups, while it lowest level. GSH-Px level did not differ increased ARS-30 when (p<0.05).Conclusion: Consequently treatment can inhibit PTZ-induced oxidative stress peripheral In addition, may provide improvements antioxidant enzymes. contribute defense system.